Age-related cerebral small-vessel disease (CSVD) is a major cause of dementia, predominantly affecting individuals over 60 years of age, with a prevalence exceeding 70% in the elderly population. However, the correlation between the burden of CSVD and the progression of cognitive impairment in young and middle-aged individuals remains uncertain. DREAM-10 is an observational, prospective study that enrolled individuals aged 30-60 years, who were free from known dementia but exhibited imaging markers related to CSVD. Through prospective registration and follow-up, this study will collect data on patients with CSVD, including clinical information, neuropsychological assessments, multimodal Magnetic Resonance Images (MRI) and retinopathy characterized by Optical Coherence Tomography Angiography (OCTA). CSVD related features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, brain atrophy, cortical superficial siderosis. Utilizing this data, the researchers aim to investigate the potential dementia risk among young and middle-aged individuals with CSVD over the forthcoming decade, along with identifying its predictive factors.
Study Type
OBSERVATIONAL
Enrollment
1,000
This does not entail the application of interventions.
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
RECRUITINGMini-mental State Examination (MMSE) score
To assess changes in cognitive function of patients. Adopt education level adjustment value (illiteracy, primary school, middle school, university respectively adopt ≤22points, ≤23 points, ≤24 points, ≤26 points) to define dementia.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
The development of total brain small vessel disease burden in MRI
Total brain small-vessel disease burden is used to assess the overall impact of CSVD, with a score range of 0-4 points.
Time frame: Baseline ,6-month, and every 1 year, follow-up time up to 10 years.
Blood flow density
Record blood flow density (%) of OCTA.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
Vascular perfusion area
Record vascular perfusion area (mm\^2) of OCTA.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
Macular fovea retinal thickness
Record macular fovea retinal thickness (μm) of OCTA.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
Retinal nerve fiber layer thickness
Record retinal nerve fiber layer thickness (μm) of OCTA.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
Resting state functional connectivity changes
The study uses Resting state functional MRI (Rs-fMRI) to measure changes of functional connectivity across regions.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
White matter Integrity
The study uses Diffusion Tensor Imaging (DTI) to obtain FA and MD values, which are used to measure changes in the integrity of white matter.
Time frame: Baseline ,6-month, and every 1 year, follow-up time up to 10 years.
Number of Patients with cerebrovascular events, cardiovascular events, or death
Cerebrovascular events included ischemic stroke, transient ischemic attack (TIA) and cerebral hemorrhage. Cardiovascular events included angina and myocardial infarction. Death included any reason caused death.
Time frame: Baseline,3-month,6-month, and every 1 year, follow-up time up to 10 years.
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