The purpose of this study is to establish bioavailability of 2 treatments with ZSP1273: 200mg tablets and 200mg granules will be given to healthy Participants under fasting conditions. Bioavailability will be evaluated and verified on the basis of pharmacokinetic data.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
32
Participants receive ZSP1273 tablet orally.
Participants receive ZSP1273 granules orally.
Guangdong Hospital of Chinese Medicine
Guangzhou, Guangdong, China
Maximum observed plasma concentration (Cmax)
The Cmax of a single dose of ZSP1273 tablet and ZSP1273 granules will be evaluated and compared.
Time frame: Day 1 to Day 20
Area under the concentration-time curve from time zero to infinity (AUCinf)
The AUCinf of a single dose of ZSP1273 tablet and ZSP1273 granules will be evaluated and compared.
Time frame: Day 1 to Day 20
Area under the concentration-time curve from time zero to last time of quantifiable concentration (AUClast)
The AUClast of a single dose of ZSP1273 tablet and ZSP1273 granules will be evaluated and compared.
Time frame: Day 1 to Day 20
Number of participants with drug-related adverse events as assessed by CTCAE v5.0
Time frame: Day 1 to Day 20
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.