The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers. The results of DPOAE and CSF will be correlated to identify statistically significant correlation.
Case-Control study Tools for patients' selection and inclusion in the study STEP one * Full medical records detailed for neurological diseases * Brain and spinal cord MRI performed 12 months (n1) before and most recent one (n2) * Lumbar puncture * Blood test * Questionnaire for screening hearing disorders * App for screening hearing loss STEP two * Pure Tone Auditory test + Tympanometry and Stapedial Reflex * Speech Perception test * In case of tinnitus: tinnitus questionnaire and acuphenometry * DPOAEs * ABR STEP three in case of Hearing impairment \- MRI Tractography
Study Type
OBSERVATIONAL
Enrollment
30
The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex * Speech Perception test * In case of tinnitus: tinnitus questionnaire and acuphenometry * DPOAEs * ABR
Cerebrospinal Fluid will be collected by lumbar puncture and analyzed
Arianna Di Stadio
Catania, Sicily, Italy
RECRUITINGAuditory functions and correlation with CSF findings
The worsening of the hearing thresholds and DPOAE results will be correlated with the presence of inflammatory elements in the CSF
Time frame: 12 months
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