The aim of this clinical trial is to evaluate the effect of low doses of antiplatelet medications (aspirin 81 mg/day or clopidogrel 75 mg/day) with or without a combination of antioxidants (N-acetylcysteine 600 mg/day) in a dry AMD patient with large drusen. Participants will divided in to three groups. * Participants who were already taking low dose antiplatelet medications. * Participants who take the antiplatelet drug mentioned above in addition to the antioxidant prescribed by the investigator * Participants does not use any medications.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
174
Patients take aspirin 81 mg per day.
Patients take clopidogrel 75 mg per day.
Patients are given N-acetylcysteine 600 mg per day.
Department of ophthalmology, Faculty of medicine, Vajira hospital, Navamindradhiraj University
Bangkok, Dusit, Thailand
RECRUITINGDrusen volume analysis
To assess AMD progression in patient with large drusen, drusen volume was measured and analyzed in each patient group by OCT scan
Time frame: 1 year
Best-corrected visual acuity change
To evaluate Best-corrected visual acuity in each patient group by ETDRS chart
Time frame: 1 year
Rate of disease progression
To evaluate disease progression to geographic atrophy or neovascular AMD by OCT scan and fundus photo
Time frame: 1 year
Side effects of medications intake
To evaluate the safety of the medication used by questionnaire
Time frame: 1 year
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