The aim was to investigate whether endoscopic balloon dilatation combined with PRP injection can help prevent or prolong restenosis in patients with Crohn's disease with colonic stenosis, and to explore the concentration of PRP. The study was a single-center, randomized, non-controlled study. Experimental group of patients underwent endoscopic balloon dilation and submucosal injection of PRP at the wound edge, historical control was used, and the patients included in the study were randomly divided into high concentration group and low concentration group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
74
Endoscopic balloon dilatation combined with autologous platelet-rich plasma (PRP) injection with different concerntrations
The Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
restenosis rate
restenosis means the endoscopy with size of 10.5mm can not pass the stricture afer endotherapy
Time frame: 3 months after endotherapy
Changes in intestinal ultrasound
the thickness of the stricture intestinal wall, and the width of the proximal intestinal cavity
Time frame: 3 months after endotherapy
Proportion of surgery
The proportion of surgery due to stenosis or perforation
Time frame: 1 year after endotherapy
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