The Use of Platelet-rich-fibrin in Lower Third Molar Surgery.

Amerigo Giudice31 enrolled

Overview

The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Facial Swelling Tooth Position Anomalies Tooth, Impacted Tooth Extraction Status Nos Tooth Avulsion

Interventions

PRFBIOLOGICAL

Post-operative PRF placement in the post-extraction socket after third molar surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 32 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 to 32 years who required both M3M extractions were recruited * Good health status * Indication to surgical extraction of both M3M * Complete root formation * Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification Exclusion Criteria: * Person under the age of 18 or over 32 * Allergy or contraindications to administration of corticosteroids * Acute infection in any of the teeth to be extracted * Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease * Pregnancy or breastfeeding * History of treatment with antiresorptive drugs * Chronic kidney disease

Locations (1)

Magna Graecia University of Catanzaro

Catanzaro, Italy

Outcomes

Primary Outcomes

Facial swelling qualitative analysis

To compare the effectiveness of PRF in reducing facial swelling using qualitative three-dimensional analysis (measured by colorimetric variation given by the overlapping volumes) .