It has been reported that non-pharmacological methods can be used as an alternative in addition to pharmacological methods to reduce pain, anxiety, stress and inflammatory response that begins with the surgical incision in the intraoperative period and continues throughout the operation. It has been reported that music can be used as an alternative non-pharmacological method to reduce pain and anxiety in the perioperative period, as well as surgical stress and the related stress response. The aim of this study is to test the hypothesis that music used as a non-pharmacological method in the intraoperative period can reduce inflammatory response in living donor hepatectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
61
Istinye University Hospital
Istanbul, Turkey (Türkiye)
Differences in Interleukin-6 (IL-6)
Serum levels of IL-6 will be measured preoperatively and postoperatively.
Time frame: 4 hours
Difference in tumor necrosis factor alpha (TNF-alfa)
Serum levels of TNF-alpha will be measured preoperatively and postoperatively.
Time frame: 4 hours
Difference between serum levels of total antioxidant capacity (TAC) at preoperative and postoperative period.
Blood samples will be collected preoperatively and postoperatively to measure serum levels of TAC. Blood samples will be stored in medical refrigerator and analysis for serum levels of TAC will be done after collection of all samples.
Time frame: 4 hours
Difference between serum levels of total oxidant capacity (TOC) at preoperative and postoperative period.
Blood samples will be collected preoperatively and postoperatively to measure serum levels of TOC. Blood samples will be stored in medical refrigerator and analysis for serum levels of TOC will be done after collection of all samples.
Time frame: 4 hours
Difference in c-reactive protein (CRP)
Serum levels of CRP will be measured preoperatively and postoperatively.
Time frame: 24 hours
Difference in alanine aminotransferase (ALT)
Serum levels of ALT will be measured preoperatively and postoperatively.
Time frame: 24 hours
Difference in aspartate aminotransferase (AST)
Serum levels of AST will be measured preoperatively and postoperatively.
Time frame: 24 hours
Difference in creatinine
Serum levels of creatinine will be measured preoperatively and postoperatively.
Time frame: 24 hours
Differences in preoperative State-Trait Anxiety Inventory scores
assessed 1 day before surgery. The total score on the scale ranges from 20 to 80 points and a higher score represents greater anxiety.
Time frame: 20 minutes
Differences in postoperative State-Trait Anxiety Inventory scores
assessed 1st day after surgery. The total score on the scale ranges from 20 to 80 points and a higher score represents greater anxiety.
Time frame: 20 minutes
Differences in pain scores
Assessed 1st, 6th, 12th and 24th hour postoperatively. (from 0 (no pain) to 10 (maximal possible pain))
Time frame: 24 hours
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