The goal of this observational study is to investigate biomarkers and neurocognitive markers of neurodegenerative processes in obstructive sleep apnea patients. The main questions the study aims to answer are: * Does neurodegeneration assessed by neurobiological markers and neurocognitive test performance exists in obstructive sleep apnea? * Are these neurodegenerative markers are associated with the adherence to clinical prescribed positive airway pressure therapy? Newly diagnosed patients with obstructive sleep apnea will be observed during the use of clinical prescribed positive pressure therapy. Different study related investigations take place before and six months after treatment start. Researchers will compare after six months the group of adherent treatment participants with the non-adherent treatment participants group to investigate if differences in the observed neurobiological or neurocognitive parameters exist.
Study Type
OBSERVATIONAL
Enrollment
136
Technische Universität Dresden, Universitätsklinikum Dresden
Dresden, Saxony, Germany
RECRUITINGConcentration of neurofilament light chain
longitudinal analysis
Time frame: From enrollment to the follow up time point after 6 months of treatment
Concentration of Neurofilament light chain
in between the groups (assessed after 6 months)
Time frame: From enrollment to the follow up time point after 6 months of treatment, in between the groups
Concentration of Glial fibrillary acidic protein
longitudinal analysis and in between the groups (assessed after 6 months)
Time frame: From enrollment to the follow up time point after 6 months of treatment
Cognitive performance measured by SDMT, MoCA
Longitudinal analysis and in between the groups (assessed after 6 months)
Time frame: From enrollment to the follow up time point after 6 months of treatment
Objective sleep parameters measured by polysomnography or equivalent measuremt methods
Longitudinal analysis and in between the groups (assessed after 6 months). For example objective parameters like apnea-hypopnea-index per hour or sleep efficacy in %.
Time frame: From enrollment to the follow up time point after 6 months of treatment
Subjective sleep parameters measured by symptoms questionnaires (Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index)
Longitudinal analysis and in between the groups (assessed after 6 months). For example parameters like sleepiness (ESS-questionnnaire, min to max 0 to 24 points) or sleep quality (PSQI-questionnaire, min to max 0 to 21 points). Lower score values represent fewer symptom load.
Time frame: From enrollment to the follow up time point after 6 months of treatment
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