Patients with interstitial lung disease present, in addition to respiratory symptoms, peripheral muscle dysfunction, which contributes to functional impairment. The aimof the study is to investigate the safetyof whole-body electrical stimulation in patients with interstitial lung disease (ILD). Patients Will perform two different EECI protocols, with na intervalo fone week between them. First the patients Will be submitted to the evaluation of the autonomic control. After a blood collection and measurement of muscles trength will be performed. The verification of vital signs: BP, SpO2, HR, FR and the perception of dyspnea and fatigue (BORG) Will occur immediately before and after the EECI session. During the protocol, SpO2, HR, RR and BORG Will be checked. After the session, a new blood collection Will be performed and autonomic control and muscle strength Will be reassessed. After 24, 48 and 72 hours, new blood samples Will be collected and muscle pain Will be measured.
Patients with ILD will be submitted to two whole body electrostimulation protocols, with an interval of one week between them. Miha Bodytec equipment will be properly calibrated, with electrodes on the quadriceps, hamstrings, glutes, biceps, triceps, pectorals, abdomen, trapezius, latissimus dorsi and quadratus lumborum muscles. Symmetric pulsed biphasic current will be used, pulse width of 400µs, frequency of 75Hz, contraction time of five seconds, rest time of 10 seconds. Protocol 1 will take eight minutes resulting in 32 muscle contractions, and protocol 2 will take 16 minutes resulting in 64 muscle contractions. Initially, patients will undergo an assessment of autonomic control. Then, blood collection will be performed, the serum lactate level will be checked and muscle strength will be measured. Verification of systolic blood pressure, diastolic blood pressure, peripheral oxygen saturation, heart rate, respiratory rate and perception of dyspnea and fatigue (BORG) will occur immediately before and after the whole body electrical stimulation session. During the protocol, peripheral oxygen saturation, heart rate, respiratory rate and BORG will be checked. After the session, the serum lactate level will be checked, a new blood collection will be performed and autonomic control and muscle strength will be reassessed. After 24, 48 and 72 hours, new blood samples will be collected and muscle pain will be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
8
Performed using Miha Bodytec equipment, properly calibrated, with electrodes on the quadriceps, hamstrings, glutes, biceps, triceps, pectorals, abdomen, trapezius, latissimus dorsi and quadratus lumborum muscles.
Peripheral oxygen saturation
Peripheral oxygen saturation will be assessed by pulse oximetry
Time frame: baseline
Peripheral oxygen saturation
Peripheral oxygen saturation will be assessed by pulse oximetry
Time frame: During the procedure: Protocol 1: minute four; Protocol 2: minute eight
Peripheral oxygen saturation
Peripheral oxygen saturation will be assessed by pulse oximetry
Time frame: Immediately after the session
Respiratory rate
Respiratory rate will be assessed by respiratory rate count for one minute
Time frame: baseline
Respiratory rate
Respiratory rate will be assessed by respiratory rate count for one minute
Time frame: During the procedure: Protocol 1: minute four; Protocol 2: minute eight
Respiratory rate
Respiratory rate will be assessed by respiratory rate count for one minute
Time frame: Immediately after the session
Heart rate
Heart rate will be assessed by pulse oximetry
Time frame: baseline
Heart rate
Heart rate will be assessed by pulse oximetry
Time frame: During the procedure: Protocol 1: minute four; Protocol 2: minute eight
Heart rate
Heart rate will be assessed by pulse oximetry
Time frame: Immediately after the session
Systolic blood pressure
Systolic blood pressure will be assessed through sphygmomanometer
Time frame: baseline
Systolic blood pressure
Systolic blood pressure will be assessed through sphygmomanometer
Time frame: Immediately after the session
Diastolic blood pressure
Diastolic blood pressure will be assessed through sphygmomanometer
Time frame: baseline
Diastolic blood pressure
Diastolic blood pressure will be assessed through sphygmomanometer
Time frame: Immediately after the session
Dyspnea and fatigue
Dyspnea and fatigue will be assessed through Borg's perceived exertion scale
Time frame: baseline
Dyspnea and fatigue
Dyspnea and fatigue will be assessed using a subjective perceived exertion scale ranging from 0 to 10, where 0 indicates no dyspnea and 10 indicates maximum dyspnea.
Time frame: During the procedure: Protocol 1: minute four; Protocol 2: minute eight
Dyspnea and fatigue
Dyspnea and fatigue will be assessed using a subjective perceived exertion scale ranging from 0 to 10, where 0 indicates no dyspnea and 10 indicates maximum dyspnea.
Time frame: Immediately after the session
Autonomic control
Autonomic control will be assessed through variability heart rate
Time frame: baseline
Autonomic control
Autonomic control will be assessed through variability heart rate
Time frame: up to 10 minutes after the session
Adverse events
Occurence of adverse events will be assessed through patient report
Time frame: Immediately after the session
Adverse events
Occurence of adverse events will be assessed through patient report
Time frame: 24 hours after the session
Adverse events
Occurence of adverse events will be assessed through patient report
Time frame: 48 hours after the session
Adverse events
Occurence of adverse events will be assessed through patient report
Time frame: 72 hours after the session
Muscle damage
Assessed through the serum level of creatine kinase (CK)
Time frame: Baseline
Muscle damage
Assessed through the serum level of creatine kinase (CK)
Time frame: Immediately after the session
Muscle damage
Assessed through the serum level of creatine kinase (CK)
Time frame: 24 hours after the session
Muscle damage
Assessed through the serum level of creatine kinase (CK)
Time frame: 48 hours after the session
Muscle damage
Assessed through the serum level of creatine kinase (CK)
Time frame: 72 hours after the session
Muscle fatigue
Assessed through the serum lactate level
Time frame: baseline
Muscle fatigue
Assessed through the serum lactate level
Time frame: Immediately after the session
Muscle fatigue
Assessed through the serum lactate level
Time frame: 3 minutes after the session
Muscle fatigue
Assessed through the serum lactate level
Time frame: 6 minutes after the session
Delayed onset muscle pain
Assessed by visual numerical scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates maximum pain
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Time frame: baseline
Delayed onset muscle pain
Assessed by visual numerical scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates maximum pain
Time frame: Immediately after the session
Delayed onset muscle pain
Assessed by visual numerical scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates maximum pain
Time frame: 24 hours after the session
Delayed onset muscle pain
Assessed by visual numerical scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates maximum pain
Time frame: 48 hours after the session
Delayed onset muscle pain
Assessed by visual numerical scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates maximum pain
Time frame: 72 hours after the session
Peripheral muscle strength
Assessed by dynamometry
Time frame: baseline
Peripheral muscle strength
Assessed by dynamometry
Time frame: up to 40 minutes after the session