Women who develop preeclampsia during pregnancy are four times more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs may be related to lasting blood vessel damage after the pregnancy but there are currently no specific treatment strategies to prevent this disease progression. This study addresses this public health issue by examining whether starting low dose aspirin therapy after pregnancy is an effective treatment for lasting blood vessel damage in order to inform better clinical management of cardiovascular disease risk in women who have had preeclampsia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
40
162mg aspirin capsule
placebo capsule
University of Iowa
Iowa City, Iowa, United States
RECRUITINGmagnitude of microvascular endothelial function
skin blood flow response to acetylcholine delivered via intradermal microdialysis
Time frame: baseline, 12 weeks
magnitude of brachial artery endothelial function
brachial artery flow mediated dilation
Time frame: baseline, 12 weeks
magnitude of microvascular endothelin-1 mediated constriction
skin blood flow response to endothelin-1 delivered via intradermal microdialysis
Time frame: baseline, 12 weeks
magnitude of microvascular nitric oxide-dependent dilation
skin blood flow response to acetylcholine + L-NAME delivered via intradermal microdialysis
Time frame: baseline, 12 weeks
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