Evaluating Simplified Layered Consent for Clinical Trials

Inclusion Criteria: * All inclusion criteria from the larger SNAP trial: 1. S. aureus complex grown from ≥1 blood culture 2. Admitted to a participating hospital at the time of eligibility assessment * Specific additional inclusion criteria for SIMPLY-SNAP: 1. Admitted to participating hospital of SIMPLY-SNAP 2. Self-reported proficiency in English or French adequate to be able to participate in consent process carried out solely in English or French (as the supplementary consent materials required in the simplified consent process are currently only available in these two languages) Exclusion Criteria: * All exclusion criteria from larger SNAP trial: 1. Time of anticipated platform entry is greater than 72 hours post collection of the index blood culture 2. Polymicrobial bacteremia, defined as more than one organism in the index blood cultures, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician 3. Patient currently being treated with a systemic antibacterial agent that cannot be ceased 4. Known previous participation in SNAP 5. Known positive blood culture for S. aureus between 72 hours and 180 days prior to the time of eligibility assessment 6. Treating team deems enrolment in the study is not in the best interest of the patient 7. Treating team believes that death is imminent and inevitable 8. Patient is for end-of-life care and antibiotic treatment is considered inappropriate 9. Patient \<18 years of age and paediatric recruitment not approved at recruiting site * Specific additional exclusion criteria for SIMPLY-SNAP: None