A Study of Remimazolam Tosilate for Sedation in the Upper Gastrointestinal Endoscopy

Inclusion Criteria: 1. patients or their guardians are able to provide a written informed consent 2. participants undergo upper gastrointestinal endoscopy 3. ≥18 years old, male or female 4. 18 kg/m2≤bmi≤30kg/m2 Exclusion Criteria: 1. Subjects to be intubated (including laryngeal mask placement); 2. Complex endoscopic diagnosis and treatment operations are required; 3. Severe cardiovascular disease within 6 months prior to signing the ICF; 4. Heart rate \< 50 beats/min during screening period; 5. Subjects with poor blood pressure control during screening; 6. Severe arrhythmias or heart disease; the circulatory system is unstable; 7. Subjects with a history of severe cardiovascular disease, or cerebrovascular disease, or neurological disease, or mental illness 8. Subjects with a history of drug abuse; 9. Abnormal values of the laboratory examination; 10. Allergic to relevant drugs ingredient or component; 11. Pregnant or nursing women; 12. Subjects who has participated in clinical trials of other interventions recently; 13. Other conditions deemed unsuitable to be included.