Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.
Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.
Study Type
OBSERVATIONAL
Enrollment
238
The Chinese University of Hong Kong
Hong Kong, Tai Po District, Hong Kong
Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)
Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire
Time frame: Baseline
Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)
The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.
Time frame: Baseline
Complex attention will be measured by the Attention Network Test (ANT)
The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0.
Time frame: Baseline
Memory and learning will be measured by the Word list learning test (WLLT)
Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition.
Time frame: Baseline
Executive functions will be measured by the category verbal fluency test (CVFT)
On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds
Time frame: Baseline
The levels of Aβ40 and Aβ42 will be measured by saliva analysis
saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection.
Time frame: Baseline
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