Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, half effective dose of remimazolam required to prevent cardiovascular response to tracheal intubation when combined with fentanyl in pediatric patients is still unknown.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
remimazolam is given intravenously
half effective dose for intubation
half effective dose of remimazolam required to prevent cardiovascular response to tracheal intubation when combined with fentanyl
Time frame: from injection of remimazolam to completed tracheal intubation, at an average of 5 minutes
cardiovascular response to tracheal intubation
cardiovascular response is defined as increase of blood pressure or heart rate higher than 20% of the baseline value by 3 minutes after intubation
Time frame: from injection of remimazolam to 3 minutes after tracheal intubation, at an average of 8 minutes
the time to loss of consciousness
Time frame: from injection of remimazolam to loss of consciousness, at an average of 3 minutes
incidence of adverse events
adverse events include bradycardia, hypotension, hypoxemia, and injection pain
Time frame: from injection of remimazolam to loss of consciousness, at an average of 3 minutes
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