This study is for people who have multiple sclerosis, acute leukemia (in remission), or long-COVID and a Body Mass Index over 27 and may struggle with cognitive issues such as remembering information, concentrating, or making decisions that affect everyday life. By doing this study, researchers hope to learn how liraglutide (Saxenda®), a weight loss drug, affects levels of a certain disease marker in the body called Brain Derived Neurotrophic Factor (BDNF). Participation in this research will last about 21 weeks.
This study is for people who have multiple sclerosis, acute leukemia (in remission), or long-COVID and a Body Mass Index over 27 and may struggle with cognitive issues such as remembering information, concentrating, or making decisions that affect everyday life. By doing this study, researchers hope to learn how liraglutide (Saxenda®), a weight loss drug, affects levels of a certain disease marker in the body called Brain Derived Neurotrophic Factor (BDNF). Previous research has shown that liraglutide may help regulate BDNF levels, which can be linked to issues with cognitive and mental performance. Participation in this research will last about 21 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
A weight loss drug that can be taken at home. Liraglutide will be provided as an injectable pen that participants can inject in the stomach, thigh or upper arm. A member of the research team will give you instructions on how to inject liraglutide using the injectable pen and answer any questions.
Participants will be asked to maintain a medication diary of each dose of liraglutide. A member of the research team will provide a copy of this diary for participants to complete. Participants will be asked to return this medication diary to research staff at each clinic visit.
University of Chicago Medicine Comprehensive Cancer Center
Chicago, Illinois, United States
RECRUITINGChange from Baseline in Serum Brain Derived Neurotrophic Factor (BDNF) after 8 Weeks
Change from baseline in serum Brain Derived Neurotrophic Factor (BDNF) levels after reaching the goal dose of GLP-1 agonist (8 weeks).
Time frame: 8 weeks
Change from Baseline in Serum Brain Derived Neurotrophic Factor (BDNF) after 4 Weeks
Change from baseline in serum Brain Derived Neurotrophic Factor (BDNF) levels at 4 weeks.
Time frame: 4 weeks
Change from Baseline in Serum Brain Derived Neurotrophic Factor (BDNF) after 12 Weeks
Change from baseline in serum Brain Derived Neurotrophic Factor (BDNF) levels at 12 weeks.
Time frame: 12 weeks
Change from Baseline in Serum Brain Derived Neurotrophic Factor (BDNF) after 21 Weeks
Change from baseline in serum Brain Derived Neurotrophic Factor (BDNF) levels at discontinuation of study drug (21 weeks).
Time frame: 21 weeks
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