Direct oral anticoagulants (DOAC) are anticoagulant molecules that act either directly on factor Xa (Apixaban, Rivaroxaban) or on factor IIa (Dabigatran). AODs interfere with most coagulation tests, especially those performed by chronometric technique. For this reason, part of the thrombophilia workup (protein S, search for lupus anticoagulants, antithrombin for patients on dabigatran) cannot be performed on DOACs at the HUS. Recent studies have highlighted the effectiveness of activated charcoal to adsorb DOACs in order to perform certain hemostasis tests.
Study Type
OBSERVATIONAL
Enrollment
200
Laboratoire d'Hématologie - CHU de Strasbourg - France
Strasbourg, France
RECRUITINGInterference or not of activated charcoal in the measurement of protein S, antithrombin, and in the search for lupus anticoagulants.
This study compares the results of two diagnostic techniques (Thrombophilia work-up under direct oral anticoagulants (DOACs)), one using activated charcoal versus another not using it
Time frame: Through study completion, an average of 6 months
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