This was a retrospective cohort study to assess the incidence rate of psoriatic arthritis (PsA) among psoriasis (PsO) patients newly initiated on secukinumab or any biologics/apremilast (small molecule). The analysis was performed in two databases, IBM® MarketScan® database: Commercial Claims and Encounters (CCAE) and Medicare Supplemental Beneficiaries (MDCR) from 01 January 2010 to 30 June 2021 and BADBIR from 01 January 2016 to 01 September 2021.
Study Type
OBSERVATIONAL
Enrollment
1,171
Novartis
Basel, Switzerland
Exposure-adjusted incidence rate of PsA per 100 patient-years among PsO patients who newly initiated secukinumab
Time frame: Up to 11.5 years
Time from secukinumab initiation to the first PsA diagnosis
Time frame: Up to 11.5 years
Age
Time frame: Baseline
Gender
Time frame: Baseline
Region
Time frame: Baseline
Insurance type
Time frame: Baseline
Ethnicity
Time frame: Baseline
Weight
Time frame: Baseline
Height
Time frame: Baseline
Body mass index (BMI)
Time frame: Baseline
Prior treatments
Time frame: Baseline
Hard-to-treat locations
Time frame: Baseline
Comorbidities
Time frame: Baseline
Dermatology Life Quality Index (DLQI)
The DLQI is a validated, 10-question, self-reported questionnaire to evaluate the patient's perception of the impact of skin disease on quality of life. The DLQI is rated on a 4-point scale (0 = not at all to 3 = very much). The highest possible total score for the DLQI is 30, and higher scores indicate more severe impact on quality of life.
Time frame: Baseline
Health Assessment Questionnaires - Disability Index (HAQ-DI)
The HAQ-DI is a 20-question scale assessing functional ability. The final HAQ-DI score ranges from 0 (no problems functioning) to 3 (not able to function).
Time frame: Baseline
Psoriasis Area and Severity Index (PASI)
The Psoriasis Area and Severity Index (PASI) is the most widely used tool for the measurement of severity of psoriasis. PASI combines the assessment of the severity of lesions and the area affected into a single score in the range 0 (no disease) to 72 (maximal disease).
Time frame: Baseline
Body Surface Area (BSA)
Time frame: Baseline
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