Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
Participants will be asked to enroll for 18-months. Each participant will complete 3 in-person study visits, then participate an a 6-month weight loss program delivered remotely. Some participants may be invited to complete 3 additional in-person visits. Study Visit activities include questionnaires, blood draws, brain MRIs, body measurement and dual energy x-ray absorptiometry (DXA) scan for body composition measurement, a breathing test, and biopsies of muscle and fat tissue. Each participant will be provided a fitness tracker and body weight scale to use throughout the study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
Behavioral Weight Loss Program is a modified version of the Diabetes Prevention Program.
Fred Hutch Cancer Center
Seattle, Washington, United States
NOT_YET_RECRUITINGUniversity of Washington - South Lake Union
Seattle, Washington, United States
RECRUITINGChange in maximal respiratory capacity (oxygen consumption rate) in peripheral blood mononuclear cells
Mitochondrial maximal respiratory capacity will be measured in fasting samples from peripheral blood mononuclear cells.
Time frame: From baseline to active weight loss (at least 21 days of weight loss equivalent or greater than 0.5 pounds per week) and from baseline to weight loss plateau (after active weight loss, at least 21 days of halted weight loss, or +/- 0.25 pounds/week).
Change in fMRI BOLD signal
fMRI BOLD signal to visual food cues within a priori brain regions of interest pre and post consuming a standardized meal. Meal-induced change will be calculated by post-pre meal BOLD signal.
Time frame: From baseline to a weight loss plateau (after active weight loss, at least 21 days of halted weight loss, or +/- 0.25 pounds/week).
Entry into involuntary weight loss plateau
binary outcome (Y/N) and time from baseline
Time frame: throughout 18-month enrollment
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