Lung Overdistension and Abdominal Pressure Rise

University of Padova20 enrolled

Overview

The goal of this pilot interventional no-profit study is to evaluate airway pressure, esophageal pressure and variations in lung volume distribution with EIT in mechanically ventilated patients admitted to our UTI with respiratory failure after the application of an abdominal weight and resulting increase of intra-abdominal pressure.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Respiratory Failure Respiratory Distress Syndrome, Adult

Interventions

Application of abdominal weightPROCEDURE

Application of variable weight on the abdomen to reach a 5 mmHg increase in IAP

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Invasive mechanical ventilation in acute respiratory failure (PaO2/FiO2 \<300 mmHg) * Need of PEEP trial * Need of urinary catheter (used to measure IAP) Exclusion Criteria: * Contraindication to EIT use * Pacemaker or other metal device in thoracic region * Contraindication to abdominal weight placement * Surgical or traumatic incision on the abdomen * Severe abdominal hypertension * Esophageal diseases that counterindicate naso-gastric tube placement * Severe hemodynamic instability (norepinephrine \> 0.1 mcg/kg/min; dobutamine or dopamine \> 5 mcg/kg/min; epinephrine every dosage) * Severe obesity (BMI \> 35 kg/m2) * Need of \> 7 kg weight to reach 5 mmHg IAP increase

Locations (1)

Azienda Ospedaliera Università di Padova

Padova, Italy

RECRUITING

Outcomes

Primary Outcomes

Variation of lung volume distribution

TID %

Time frame: through study completion, an average of 1 year

Variation of airway pressure

cmH2O

Time frame: through study completion, an average of 1 year

Variation of esophageal pressure

cmH2O

Time frame: through study completion, an average of 1 year

Central Contacts

Paolo Persona, MD, PhD

CONTACT

+39 3389745902 ppersona75@gmail.com

Data from ClinicalTrials.gov

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