Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Inclusion Criteria: * Hospitalized participants with a prior diagnosis of COPD including spirometry within the prior year documenting a postbronchodilator FEV1/FVC ≤ 0.7 and an FEV1 ≤ 80%, and a clinician identified admitting diagnosis of AECOPD: acute increase in dyspnea, sputum volume or purulence - without other attributable cause. * Participants must have a moderate exacerbation of COPD according to the Rome guidelines * ≥ 10 pack-years smoking history. Exclusion Criteria: * Endotracheal intubation or mechanical ventilation. * Participants with severe exacerbation of COPD according to the Rome guidelines * Participants with signs and symptoms consistent with an alternative diagnosis for worsening of pulmonary status * Interstitial lung disease. * Current or prior history of asthma. * Known hypersensitivity, allergy, or reaction to polyethylene glycol (PEG) * Preexisting autoimmune disease: History of autoimmune disease and/or use of chronic steroids of \>10mg/d (prednisone or equivalent) for more than 14 days prior to enrollment * Current renal dialysis or renal dialysis planned or anticipated in the next 7 days. * Has confounding medical conditions, including: 1. diabetic coma, 2. uncontrolled New York Heart Association Class IV congestive heart failure, 3. uncontrolled angina, 4. stroke or transient ischemic attack (TIA) within 4 weeks before study entry, 5. clinically significant arrhythmias not controlled by medication, or 6. idiopathic pulmonary fibrosis, * Has a weight \>120 kg at Screening. * Known pregnancy, a positive pregnancy test at screening, or lactation for WOCBP. * Has systemic immunosuppression/immune deficiency