Preoperative Administration of Lugols Solution in Toxic Thyroid Diseases (TD): A Prospective Study

Aristotle University Of Thessaloniki50 enrolled

Overview

Lugol's solution and other preparations containing iodide have been used as an adjuvant treatment in patients with toxic disease planned for thyroidectomy. However, no conclusive evidence supporting the benefits of preoperative treatment with LS for patients with toxic goiters. This trial aims to provide new insights into future recommendations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Toxic; Thyroid

Interventions

Lugol's iodine solution 5%DIETARY_SUPPLEMENT

4 drops of LS every 8 hours for 10 days preoperatively will be given

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients ≥18 years of age * Toxic thyroid disease, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy * Written informed consent Exclusion Criteria: * prior thyroid or parathyroid surgery, * hyperparathyroidism that requires associated parathyroidectomy, * thyroid cancer that requires adding a lymph node dissection, * iodine allergy, * consumption of lithium or amiodarone, * medically unfit patients (ASA-IV), * breastfeeding women, * preoperative vocal cord palsy and * planned endoscopic, video-assisted or remote access surgery.

Locations (1)

3rd Surgical Department of Aristotle University, AHEPA University Hospital, Thessaloniki

Thessaloniki, Thessaloniki, Greece

Outcomes

Primary Outcomes

Thyroidectomy complications rate

postoperative bleeding, hypoparathyroidism and recurrent laryngeal nerve palsy will be recorded

Time frame: 24 hours postoperatively