Study of the Blood and Skin Immunological Profile of Patients With Recessive Dystrophic Epidermolysis Bullosa: in Vivo Analysis and the Impact of Placental Stem Cells in Vitro

Inclusion Criteria: EBDR patients : * Patients aged 18 to 80 years old * Clinically, histologically, and/or genetically confirmed intermediate, reversed or generalized, moderate to severe EBDR Healthy controls : * Adults aged 18 to 80 years old * PBMC healthy donors: subjects who have donated blood to the EFS according to the indication criteria who have consented to the use of their samples for research purposes. * Healthy skin biopsy donors: subjects undergoing abdominoplasty scheduled in plastic surgery and who have given their consent for the collection of a skin biopsy from post-operative abdominoplasty skin remnants. * Healthy donors of bandages soiled with exudates from cutaneous wounds: subject consulting a plastic surgery department as part of their usual post-operative follow-up, who have given their consent for the collection of one of their dressings during their usual during their usual renewal. For all subjects : * Free, informed, written consent, signed by the person and the investigator no later than the day of inclusion and before any examination carried out as part of the study. * Person affiliated or benefiting from a social security scheme Exclusion Criteria: EBDR patients : * EBH with no definite diagnosis or other than EBDR intermediate, reversed or generalized * Systemic anti-inflammatory or immunosuppressive therapy for less than one month * Refusal of skin biopsy Healthy controls : * Acute or chronic systemic or cutaneous inflammatory disease at the time of sampling * Current immunosuppressive anti-inflammatory treatment in the month prior to sampling For all subjects: * Persons under guardianship or curatorship, or deprived of their liberty by judicial or administrative decision * Patients receiving State Medical Aid * Pregnant or breast-feeding women