Postoperative delirium is a common complication after surgery. The underlying pathophysiology of this complication is unclear, however neuroinflammation and oxidative stress secondary to surgery had shown to be the cause of postoperative cognitive dysfunction and delirium. Erythropoietin represents non-erythropoietic effects of anti-inflammatory properties. The aims of this study were to determine the role of erythropoietin toward the development of postoperative delirium, in terms of changes in inflammatory reaction by affecting the innate immunity in elderly patients undergoing total joint arthroplasty surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
76
500 IU/kg of erythropoietin is given 3 times for each patient: the day before surgery, start of surgery and on postoperative day 1.
The same amount of normal saline is given 3 times for each patient: the day before surgery, start of surgery and on postoperative day 1.
Department of Anesthesiology and Pain medicine, Severance Hospital, Seoul, South Korea
Seoul, South Korea
Incidence of delirium
Development of postoperative delirium determined by validated evaluation tests.
Time frame: 2 days post surgery, 5 days post surgery
Inflammatory biomarker
Preoperative and postoperative comparison of inflammatory biomarkers (IL-1, IL-6, TNF-a)
Time frame: before surgery, after surgery, 3 days post surgery day 3
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