This prospective study is subject to approval of institutional medical research ethics committee. Patient undergoing second cycle IVF will be enrolled into the intervention group. Intervention involved using a clinical decision support tool, Opt-IVF to guide gonadotrophins dosing and trigger dates for a personalized controlled ovarian stimulation cycle based on the distribution of follicle sizes on day 1 and day 5, and hormone dosages given on day 1 to 4. Patients will undergo transvaginal ultrasound exam on day 1 and day 5 of the cycle to determine the number and size of follicles present. The data is used in the Opt-IVF decision support tool to suggest Gonadotropin dosage for D5 and beyond and to recommend the antagonist start day and trigger day. Clinical investigators will not override the Opt-IVF recommended dosage in any patients.
The total dosage of gonadotrophin, number of good quality oocytes and blastocyst will be analyzed from each arm.
Study Type
OBSERVATIONAL
Enrollment
30
total dosage in IU
Advanced Reproductive Centre
Kuala Lumpur, Kuala Lumpur, Malaysia
total cumulative dosage of Gonadotropins
number of total dosage that utilize during one cycle of IVF treatment
Time frame: for 1 year duration
Total number of matured oocytes
number of matured oocytes following the stimulation protocol
Time frame: for 1 year duration
total number of good quality blastocyst
total blastocyst achieved after each sti,ulation protocol
Time frame: for 1 year duration
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