The Diagnostic and Prognostic Value of Presepsin in Sepsis

University of Foggia90 enrolled

Overview

Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment. Particularly, endotoxin can be removed from the blood by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA). No studies compared presepsin to procalcitonin and endotoxin in patients treated with PMX-HA. The investigators aim to evaluate the trend and prognostic value of presepsin versus procalcitonin and endotoxin in ICU patients with septic shock from complicated major abdominal surgery, treated with PMX-HA.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Septic Shock

Interventions

presepsin, procalciton, endotoxinDIAGNOSTIC_TEST

measurement of presepsin, procalciton, endotoxin plasmatic levels

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * caucasian patients * patients undergoing laparoscopic major abdominal surgery Exclusion Criteria: * pregnancy, * organ transplantation, * palliative care * metastatic cancer * head trauma and polytrauma * coagulopathies * use of anticoagulants * neurological disease * autoimmune disease * thyroid disease.

Locations (1)

Ospedali Riuniti

Foggia, Apulia, Italy

Outcomes

Primary Outcomes

incidence of mortality at 30-days

incidence of mortality

Time frame: up to 30 days

Data from ClinicalTrials.gov

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