LSM and SSM for the Diagnosis of CSPH: a Prospective Cohort Study

McGill University Health Centre/Research Institute of the McGill University Health Centre200 enrolled

Overview

The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease. The main question it aims to answer are: \- what are the cut-off values for non-invasive tests (NITs) (including LSM, SSM) that predict the presence and occurrence of hepatic decompensation in individuals with advanced chronic liver disease? Participants will undergo regular study visits involving non-invasive tests (LSM, SSM) and assessments to monitor hepatic decompensation over the study period.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Advanced Chronic Liver Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age above 18years old * Advanced chronic liver disease (defined as LSM ≥ 10kPa) * Ability to provide informed consent Exclusion Criteria: * Transjugular intrahepatic portosystemic shunt * previous liver transplantation * Abnormality of the porto-mesenteric system (portal vein thrombosis, splenic vein thrombosis, splenectomy, portal cavernomatous transformation, porto-caval shunts) * Hematological malignancy

Locations (1)

McGill University Health Centre

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Number of patients diagnosed with portal hypertension using elastography techniques

We will assess the diagnostic accuracy of liver and spleen stiffness measurements for portal hypertension

Time frame: At baseline

Secondary Outcomes

Identifying patients at high-risk of liver related events using elastography techniques

We will use liver and spleen stiffness measurements to identify patients at risk of developing liver -related events

Time frame: 5 years