Leukoaraiosis (LA) corresponds to an alteration of the encephalic white matter, linked to chronic hypoxia. Its pathophysiology, which has been partially elucidated, is underpinned by chronic changes in the walls of small-caliber perforating arteries, leading to chronic hypoperfusion of the white matter, associated with dysfunction of the blood-brain barrier. In affected areas, this process leads to myelin rarefaction, axonal loss, perivascular alterations and the appearance of cavitation zones. Its existence is mainly linked to the presence of vascular risk factors, most notably arterial hypertension. MR fingerprinting is an innovative Magnetic resonance Imaging (MRI) technique allowing to obtain a multiparametric MRI sequence in a non-invasively way and in a single acquisition, generating not only multiple contrasts, but also absolute longitudinal relaxation time (T1) and transverse relaxation time (T2) mappings (T1 and T2 mapping). However, the prognostic role of these T2 values, in terms of ischemic, hemorrhagic and cognitive risk, has never been studied. The objective of this study is to study and compare changes in T1 and T2 values of White Matter Hyperintensities (WMH) and Normal Appearing White Matter (NAWM) in subjects with LA.
Study Type
OBSERVATIONAL
Enrollment
250
This method allows to get quantitative magnetic resonance imaging for the simultaneous measurement of multiple tissue properties in a single, time-efficient acquisition
Grupement des Hôpitaux de l'Institut Catholique de Lille
Lomme, France
RECRUITINGT1 (seconds)
T1 will be measured by three-dimensional, magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging
Time frame: 30 months
T2 (milliseconds)
T2 will be measured by three-dimensional segmented echo-planar-imaging (3D T2 EPI)
Time frame: 30 months
Correlation coefficient and its 95% confidence interval between WMH T1 and T2 values, and WHM lesion volume.
Correlation between T1 and T2 values and WHM lesion volume will be assessed by Pearson's or Spearman's correlation coefficient in the absence of normality, and its 95% confidence interval. Correlation will be considered very good if \|ρ\| \> 0.8; good if \|ρ\| is between 0.61 and 0.8; moderate if \|ρ\| is between 0.6 and 0.41; poor otherwise.
Time frame: 30 months
Correlation coefficient and its 95% confidence interval between T1 and T2 values of WMH and NAWM, lesion volume of WMH, and number of microbleeds
Correlation between T1 and T2 values and WHM lesion volume will be assessed by Pearson's or Spearman's correlation coefficient in the absence of normality, and its 95% confidence interval. Correlation will be considered very good if \|ρ\| \> 0.8; good if \|ρ\| is between 0.61 and 0.8; moderate if \|ρ\| is between 0.6 and 0.41; poor otherwise.
Time frame: 30 months
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