Interference by Activated Protein C Resistance in the Determination of Protein S Activity

University Hospital, Strasbourg, France9,470 enrolled

Overview

Protein S is an anticoagulant protein and a cofactor of protein C. It is recommended to explore it first by a functional (chronometric) technique by assessing its cofactor activity of activated protein C. Existing tests measure the prolongation of a coagulation time. These tests are all dependent on factor V, but some patients have mutations in factor V (including V Leiden) that make them resistant to activated protein C activity. It is suspected that these mutations lead to underestimations of protein S activity by chronometric technique.

Study Type

OBSERVATIONAL

Enrollment

9,470

Conditions

Resistance to Activated Protein C in the Determination of Protein S Activity

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: * Patient of legal age (≥ 18 years) * Patient for whom a sample has been sent to the HUS Hematology Laboratory for measurement of protein S activity between 28/12/2009 and 29/12/2020 * Patient who does not object to the reuse of his/her medical data for scientific research purposes. Exclusion criteria: * Minor patient * Patient with incomplete data

Locations (1)

Laboratoire d'Hématologie - CHU de Strasbourg - France

Interference by Activated Protein C Resistance in the Determination of Protein S Activity

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts