CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism

Xiao Chen60 enrolled

Overview

This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative pathological or follow-up results as reference standards.

1. Record the course of disease, the laboratory examination (e.g., potassium, aldosterone, aldosterone-to-renin ratio, intravenous salt-loading test or captopril test) and the results of adrenal vein sampling in patients with clinically suspected PA. 2. PET image analysis: Record and evaluate the following indicators: the maximum standardized uptake value (SUVmax) of lesions, the mean standardized uptake value (SUVmean) of normal liver, the SUVmean of adjacent normal adrenal tissue, the ratio of the lesional SUVmax to the normal liver SUVmean (LLR), and the ratio of the lesional SUVmax to the adjacent adrenal tissue SUVmean (LAR). 3. Pathological analysis: Hematoxylin and eosin staining and immunohistochemical analyses will be performed. Immunohistochemical analysis will be used to investigate the expression of aldosterone synthase (CYP11B2) and CXCR4.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Primary Aldosteronism

Interventions

CXCR4DIAGNOSTIC_TEST

Patients with clinical suspected primary aldosteronism will receive a CXCR4 PET imaging.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Persistent hypertension with blood pressure \> 150/100 mmHg, refractory hypertension (blood pressure \>140/90 mmHg with combined use of three types of antihypertensive medications, including diuretics), or with hypokalemia of blood pressure \>140/90 mmHg; 2. Refractory hypertension with an aldosterone-to-renin ratio (ARR) ≥ 2.0 (ng/dl)/(mU/L); 3. Positive intravenous salt-loading test or captopril test; 4. Hypertension and adrenal lesions; 5. Patient ≥18 years of age at the time of consent; 6. Provided written informed consent authorisation before participating in the study. Exclusion Criteria: 1. Refusal by the patients to undergo CXCR4 PET imaging, adrenal vein sampling, superselective adrenal arterial embolization or adrenalectomy; 2. Suspicion of familial hyperaldosteronism type 1 (FH-1) or type 3 (FH-3)； 3. Suspicion of adrenocortical carcinoma； 4. Severe comorbidity potentially interfering with treatment or HRQoL； 5. Requirement of medication interfering with the study protocol； 6. Pregnancy or lactation； 7. Estimated glomerular filtration rate \<40 mL/min/1.73 m².

Locations (1)

Department of Nuclear Medicine, Daping Hospital of Army Medical University

Chongqing, Chongqing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Standardised uptake values

Standardised uptake values of suspected adrenal disease in CXCR4 PET imaging

Time frame: completed within one week after the PET examination

Secondary Outcomes

Immunohistochemical results

Immunohistochemical evaluation of postoperative adrenal specimens

Time frame: completed within one week after surgery

Central Contacts

Xiao Chen, Ph.D

CONTACT

+8615922970174 xiaochen229@foxmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.