Interest of High-dose Gentamicin Cement Associated With Clindamycin in Changes of Hip and Knee Prostheses

University Hospital, Strasbourg, France300 enrolled

Overview

A hip or knee prosthesis can be cemented or not. The team of orthopedic surgeons from the CCOM (Centre de Chirurgie Orthopédique et de la Main) has been cementing all hip and knee prosthesis poses for many years using gentamycin cement as recommended by the French Society of Orthopedic Surgery. and trauma (SOFCOT) (1). Data obtained from the Norwegian Register of Hip Prostheses show that the best survival curve for these prostheses is found for prostheses cemented with gentamycin cement (all causes combined). Independently of the risk of aseptic loosening, infection on the prosthesis is the second complication of arthroplasty. The defense mechanism against pathogens in contact with an implant is the formation of a biofilm. Biofilm bacteria are metabolically inactive and characterized by stationary growth. Due to their slower replication, bacteria in biofilm are up to 1000 times more resistant to antibiotics. Therefore, the optimization of local antibiotic prophylaxis is essential.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Hip or Knee Replacement

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: * Adult subject (≥18 years old) * Patient operated on at the HUS between 01/02/2017 and 31/01/2019, for replacement of hip and knee prostheses * Patient having given their consent for the reuse of their data for the purposes of this research Exclusion criteria: \- Patient who expressed their opposition to participating in the study

Locations (1)

Outcomes

Primary Outcomes

Retrospective study of surgical site infections (SSI) after changes of hip and knee prostheses

Retrospective description of the benefit of high-dose gentamicin cement combined with clindamycin in hip and knee prosthesis changes

Time frame: Through study completion, an average of 3 months