The objective of this study is to examine if calcium and vitamin D supplements and/or prune can prevent bone loss in postmenopausal women.
Two hundred randomly assigned to one of two treatment groups: 1) 30 g prunes and 2) control (0 g prunes). Both groups received 500 mg calcium and 400 IU Vitamin D as a daily supplement. Blood samples are collected at baseline, 12 and 24 months to assess biomarkers of bone turnover. Physical activity recall and food records are obtained at baseline, 12 and 24 months to examine physical activity and dietary confounders as potential covariates. Dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) will be completed at baseline, 12 and 24 months to examine bone mineral density and structure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
200
30 g of prune/day
San Diego State University
San Diego, California, United States
RECRUITINGChanges from baseline in bone mineral density at 12 and 24 months
bone mineral density as assessed by dual energy x-ray absorptiometry
Time frame: Baseline, 12 months, and 24 months
Changes from baseline in bone specific alkaline phosphatase at 12 months and 24 months
bone specific alkaline phosphatase (BAP) as assessed with ELISA
Time frame: Baseline, 12 months, and 24 months
Changes from baseline in tartrate acid phosphatase-5b at 12 months and 24 months
tartrate acid phosphatase-5b (TRAP5b) as assessed with ELISA
Time frame: Baseline, 12 months, and 24 months
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