The usual coping mechanism with chronic pain is distraction, It is unclear whether the opposite, sensory monitoring, can benefit patients with chronic low back pain (cLBP). The study assesses the feasibility and acceptability of a 2-minute phone-based attention exercise, used several times a day over 8 weeks plus a 1-hour introduction, in patients with cLBP. The attention exercise is based on mindfulness-based interoceptive exposure, a task that has been tested before in a mixed pain population in Australia.
Mind your Pain (MyP), also known as Mindfulness-based Interoceptive Exposure Therapy (MIET) is an innovative brief mindfulness-based task, developed within the frame of mindfulness-based cognitive therapy, and has been pilot tested in a small cohort of 15 patients with chronic musculoskeletal pain, the majority with cLBP, in Australia. It consists of an individual guided 1-hour introduction session and a 1 to 2-minute attention task subsequently performed several times per day over 12 weeks. The task will be provided by a smart phone app and be sent to participants as phone message reminders at up to 5 times per day: according to participant preference once in the morning and once at bedtime, as well as up to 3 additional times when participants are asked to use the app whenever they perceive the pain at its worst. The task is to focus on the most intense pain sensation in a detached and equanimous way and carefully observe potential changes in five aspects of that sensation: space (region/ borders/ immobile/ moving); sense of mass (heavy/ neutral/ light), temperature (cold/ warm/ hot/ neutral); density (dense/ solid/ loose/ constricted), and borders (diffuse/ sharp). This neutral sensory-descriptive interoceptive attention focus is aiming at preventing the learned aversive response to pain that entails ruminating thoughts, and negative affect rather than immediate sensory awareness. The pilot study in 15 chronic pain patients showed significant beneficial pre-post effects (Cohen's d, ES) of 0.96 for pain anxiety, 0.86 for pain duration and 1.37 for pain intensity, maintained at 2-month follow-up. The investigators offer the MyP-MIET to patients in the US with clearly defined chronic low back pain over 8 weeks, validate it with 30 participants for feasibility and acceptability and exploratory self-report key pain outcomes and objectively (using QST and fMRI), who fit a low interoceptive awareness phenotype. The investigators also use qualitative exit interviews.
Study Type
OBSERVATIONAL
Enrollment
see above: attention exercise based on phone app
University of California San Francisco; Osher Center for Integrative Health
San Francisco, California, United States
app usage
acceptability/feasibility: number of app uses
Time frame: daily over 8 weeks
Pain, Enjoyment of life and General activity scale (PEG)
scale range is 0-30, higher scores are worse outcome. change in PEG scores for combined pain intensity and pain interference
Time frame: pre-post 8 weeks
Numeric Rating Scale (NRS) for pain intensity in the past 7 days. Range 0-10, with 10 worst pain.
pain intensity
Time frame: past 7 days
Quantitative Sensory Testing (QST), pain threshold to thermal stimulus
QST measures pain threshold with a heat stimulus in a pain physiology laboratory.
Time frame: pre-post 8 weeks
resting state functional Magnetic Resonance Imaging (rsfMRI)
rsfMRI assesses the structural integrity of the brain and detects changes in grey cortical thickness in distinct brain areas. Reduced thickness indicates less neural density.
Time frame: pre-post 8 weeks
fMRI connectivity
Using a thermal stimulus in the MRI scanner, changes from before to after the intervention in fMRI connectivity between distinct brain areas can be detected.
Time frame: pre-post 8 weeks
Multidisciplinary Assessment of Interoceptive Awareness (MAIA)
This is an 8-scale instrument, each ranging 0-5, with higher scores indicating higher interoceptive awareness, in order to assess pre-post changes.
Time frame: pre-post 8 weeks
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