Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care. In the intensive care setting, it is common to withhold food from patients during treatment of DKA. However, there is no evidence or current literature supporting this practice. The following proposed research investigates the initiation of an early diet versus withholding food during the treatment of diabetic ketoacidosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
200
Participants in the treatment arm will be initiated on a clear liquid diet on day 1 of medical ICU admission. Diet will be progressed on day 2 to full liquid diet or diabetic diet as patient tolerates based on which diet the patient would prefer.
University Medical Center
Lubbock, Texas, United States
Resolution of DKA
Defined as a closed anion gap. Adjusted Anion Gap defined as (Blood Sodium - Blood Chloride - Blood Bicarbonate) + 0.25 x ((normal albumin (4.0)) x (observed albumin)); Elevated Anion Gap is \>12
Time frame: Typically resolution of DKA is 24-72 hours, may be up to 5 days in some patients
Length of stay in the medical intensive care unit (in days).
The time from admission order is placed to the time the transfer to another unit order is placed
Time frame: Days (Typically 3-5 days in the MICU, may be up to 1 week).
Length of stay in the hospital
from admission order time to the discharge order time
Time frame: 3-7 days, may be up to 1-2 weeks.
mortality
If patient passes away within 30 days of participating in the study
Time frame: 30 day
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