Propofol for Prophylaxis of Morphine Induced Pruritis in Caesarean Section

Assiut University200 enrolled

Overview

the goal of this randomized clinical trial is to find the optimum sub hypnotic dose of iv propofol that prevents the incidence of itching induced from intrathecal morphine used in spinal anesthesia in caesarean section operation. the main questions it aim to answer are the number of patients complained of pruritus in the first 24 hours post operative period and the severity of the pruritus. participants will be divided into 4 groups. 1st group receives 0 mg of propofol , 2nd receives 10 mg , 3rd receives 20 mg and the 4th receives 30 mg.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

200

Conditions

Pruritus Caused by Drug

Interventions

PropofolDRUG

trying different dosages of propofol 10mg/ml IV to determine the prophylactic dose for morphine induced pruritis

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. The study is scheduled for women undergoing elective caesarean section under spinal anesthesia. 2. The subject is ≥ 20 years and ≤ 40 years. 3. No obvious abnormalities in preoperative ECG, blood routine, electrolytes, and other tests. 4. ASA class 1-2. Exclusion Criteria: * Patients who had a known allergy to propofol, morphine, or bupivacaine. * Those with preexisting pruritus caused by pregnancy, a coexisting skin disorder, or other pruritogenic systemic diseases. * Patients with a contraindication to spinal anaesthesia * Failed block * Need of extra sedation intra-operative * Positive history for asthma or COPD. * Patient refusal

Outcomes

Primary Outcomes

number of participants complained of pruritus in the first 24hr post operative period

Time frame: first 24 hours post operative period

Central Contacts

Sohila K Hassan, MBBCH

CONTACT

201010328326 khaledsohila@gmail.com

Data from ClinicalTrials.gov

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