This randomized, double-blind, placebo-controlled trial assessed the impact of a dietary fiber supplement (glucomannan, inulin, and psyllium) on weight and metabolic parameters in individuals with obesity-related genetic polymorphisms (FTO, MC4R, LEP, LEPR). Participants were adults aged 18-65 with a BMI ≥ 25 and confirmed genetic predispositions. The study, involving 216 participants (108 per group), ran over 12 weeks with assessments at 0, 4, 8, and 12 weeks. Primary outcome was Body-weight change in %. The study aimed to clarify the role of fiber supplements in genetically predisposed obese individuals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
108
the subjects recieved fiber supplement containing glucomannan, inulin, and psyllium
the subjects recieved placebo
Center of New Medical Technologies
Novosibirsk, Novosibisk Region, Russia
Body-weight change in %
Time frame: 180 days
body-weight reduction ≥5%
Time frame: 180 days
body-weight reduc-tion ≥10%
Time frame: 180 days
Body weight in kg
Time frame: 180 days
Body mass index change in %
Time frame: 180 days
Fat mass change in %
Time frame: 180 days
Systolic blood pressure in mmHg
Time frame: 180 days
Fat-free mass change in kg
Time frame: 180 days
Visceral fat rating change from baseline
Time frame: 180 days
Diastolic blood pressure in mmHg
Time frame: 180 days
Total cholesterol ratio
Time frame: 180 days
LDL-C ratio
Time frame: 180 days
HDL-C ratio
Time frame: 180 days
Triglycerides ratio
Time frame: 180 days
hsCRP ratio
Time frame: 180 days
Fasting plasma glucose mmol/l
Time frame: 180 days
Side effects %
any side effects or adverse events reported by subjects
Time frame: 180 days
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