An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification. Irritative contact dermatitis describes these patterns of reaction in response to toxicity of chemicals on the skin cells, which trigger inflammation by activation of the innate immune system.
An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification. Irritative contact dermatitis describes these patterns of reaction in response to toxicity of chemicals on the skin cells, which trigger inflammation by activation of the innate immune system. Therefore, the aim of this study was to see if omega cream, as proposed by its mechanism of action, could improve SLS induced contact dermatitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
25
Rilastil Difesa Sterile cream
no treatment
School of Medicine
Split, Croatia
RECRUITINGTEWL measurement with Khazaka probe
Transepidermal water loss
Time frame: through study completion, an average of 1 year
hydration measurement with corneometer probe
corneometer assessed stratum corneum hydration level
Time frame: through study completion, an average of 1 year
erythema measured with mexameter
mexameter assessed redness
Time frame: through study completion, an average of 1 year
clinical score according to dermatologist scale
Skin response to irritation and treatment will be assessed using a five-point scale to describe changes in skin erythema, roughness, scaling, oedema, and fissure
Time frame: through study completion, an average of 1 year
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