Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD

Dong Yang100 enrolled

Overview

Comparison of aerosol inhalation and intravenous glucocorticoid in the treatment of severe AECOPD-------Multicenter, prospective, randomized, controlled clinical study

This study aims to compare the efficacy and comprehensive benefits of aerosol inhalation and intravenous injection of glucocorticoids in severe AECOPD patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Interventions

aerosol inhalation of glucocorticoidsDRUG

Patients with severe AECOPD were continuously recruited from the care unit of Respiratory and Critical Care Medicine Department of the First Hospital of Jilin University to conduct a randomized cohort study, which was divided into aerosol inhalation group and intravenous glucocorticoid group. Subjects in the intravenous hormone group received 40mg methylprednisolone (dissolved in 0.9% normal saline /5% glucose injection 50ml) intravenously once a day. It lasts for 5 days. The atomized inhalation

intravenous injection of glucocorticoidsDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: (1) Patients with AECOPD requiring hospitalization or emergency treatment (COPD acute attacks combined with respiratory failure were eligible). (2) 18 years of age ≤80 years of age (3) Patients and their families are willing to participate in clinical research and sign informed consent. Exclusion Criteria: 1. Combined with tuberculosis. 2. Combined bronchiectasis. 3. complicated with definite infectious diseases. 4. PCT≥0.5ng/ml or CRP≥30mg/L. 5. Serious injury combined with other organ functions 6. Contraindications to other glucocorticoid use. 7. Concomitant bronchial asthma or positive bronchodilation test

Locations (1)

The First Hospital of Jilin University

Changchun, Jilin, China

Outcomes

Primary Outcomes

Relevant indexes after treatment

Changes in blood gas indexes (oxygenation index, arterial partial pressure of carbon dioxide, pH value) of patients with respiratory rate, blood pressure, heart rate changes

Time frame: The day of admission, day one, day two, day three, day five, day seven, day ten

Data from ClinicalTrials.gov

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