The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.
The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.
Study Type
OBSERVATIONAL
Enrollment
200
We develop and validate clinical models to predict patient survival and gene signatures in ovarian metastases of colorectal cancer.
Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
RECRUITINGOverall survival
Overall survival was defined as the time from surgery to death, or to the last follow-up.
Time frame: At least 3-year follow up
Disease-free survival
Disease-free survival was defined as the interval between surgery and the first peritoneal or distant relapse or death from any cause.
Time frame: At least 1-year follow up
Peritoneal-free survival
Peritoneal-free survival was defined as the interval between surgery and the first peritoneal relapse. Ovarian metastasis has been shown to be a subtype of peritoneal metastasis.
Time frame: At least 1-year follow up
Rates of key gene mutation
Rates of key gene mutation, such as microsatellite instability-high/DNA mismatch repair
Time frame: At least 1-year follow up
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