To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen receptor polymorphism undergoing intracytoplasmic sperm injection (ICSI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Transdermal testosterone gel application prior to ovarian stimulation in the study group.
No pretreatment prior to the ovarian stimulation in the control group.
Instituto Bernabeu
Alicante, Alicante, Spain
Number of COC (cumulus-oocyte complexes)
If number of COC is higher at least by 1.5 in the experimental group.
Time frame: Egg collection day (between 8 and 14 days after starting of ovarian stimulation)
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