This is a retrospective and prospective real-world clinical study of molecular typing in the treatment of advanced thyroid cancer. The retrospective study : Patients with advanced thyroid cancer who received precise treatment in the 24 participated hospitals from January 2020 to December 2023 were retrieved. The number of previous treatment lines was not limited. Patients who met the inclusion criteria were screened according to the inclusion and exclusion criteria. Demographic information, clinical characteristics, tumor treatment history, medication regimen, adverse reactions, molecular test results, survival follow-up results and other data were collected. The prospective study : Patients with advanced thyroid cancer who received precise treatment in the 24 Chinese hospitals from January 2024 to April 2027 were enrolled.
see:Arms and Interventions
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
800
advanced thyroid cancer patients who harbor BRAF V600E mutation
advanced thyroid cancer patients who harbor NTRK mutation
advanced thyroid cancer patients who harbor RET fusion or medullary thyroid carcinoma patients who habor RET mutation.
For patients with medullary carcinoma, if there is no RET gene mutation or RET gene mutation is unknown
Advanced thyroid cancer patients who don't harbor the above gene mutation or could not afford the cost of precision treatment even with the above gene mutation
Advanced thyroid cancer patients who had other treatment targets not included above
Fujian Cancer Hospital
Fuzhou, Fujian, China
RECRUITINGHenan Cancer Hospital
Zhengzhou, Henan, China
RECRUITINGUnion Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China
RECRUITINGCaixia Liu
Hohhot, Inner Mongolia, China
RECRUITINGFudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
RECRUITINGShanxi Cancer Hospital
Shanxi, Taiyuan, China
RECRUITINGZhejiang Cancer Hospital
Hangzhou, Zhejiang, China
RECRUITINGPeking union medical college hospital
Beijing, China
RECRUITINGObjective Response Rate(ORR)
Complete remission rate+ partial remission rate
Time frame: up to approximately 3 years
Duration of Response(DOR)
Time from the date of first partial remission or complete remission to the date of disease progression, or death of any cause, or date of lost follow-up, whichever comes first, otherwise subject data were censored at time last known disease free.
Time frame: up to approximately 3 years
Disease Control Rate(DCR)
Complete remission rate+ partial remission rate+stable disease rate
Time frame: up to approximately 3 years
Time to response(TTR)
Time from the initiation of the treatment to the first remission
Time frame: up to approximately 3 years
Progression Free Survival(PFS)
Time from the date of enrollment to of disease progression, or death of any cause, or date of lost follow-up, whichever comes first, otherwise subject data were censored at time last known disease free.
Time frame: up to approximately 3 years
Overall survival(OS)
Time from the date of enrollment to data of death from any cause, or date of lost follow-up, whichever comes first, and otherwise censored at time last known alive.
Time frame: up to approximately 3 years
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