İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin

N/ACompletedNCT06200129

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital93 enrolled

Overview

With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases, and scattered white spots lesions associated with lymphatic stasis and inflammation in the duodenum.

During esophagogastroduodenoscopy (EGD), rarely encountered lesions in the duodenum present as scattered white spots (SWS) on the normal mucosa. Although not fully understood in terms of specific association with any particular disease and clinical significance, some studies have often observed chronic non-specific duodenitis (CND) and intestinal lymphangiectasia (IL) in lesions with SWS. This condition is thought to be related to lymphatic stasis. Patients included 63 individuals with identified SWS during EGD and 30 patients with a normal appearance of the duodenal mucosa were selected as the control group. SWS lesions were categorized into two groups, grade 1 and grade 2, based on the degree of density and endoscopic appearance. Biopsies were taken from the duodenum, antrum, and corpus. It was examined for IL, CND, giardiasis, and villous atrophy. Venous blood samples were collected from all patients for serum zonulin levels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Duodenal Diseases White Spot Lesion

Interventions

sws grade 1DIAGNOSTIC_TEST

Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 1.

sws grade 2DIAGNOSTIC_TEST

Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 2

controlDIAGNOSTIC_TEST

Group of patients without scattered white lesions in the dueodenum on endoscopy.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with scattered white patchy lesions in the duodenum on endoscopy and control group patients with normal duodenum on endoscopy. Exclusion Criteria: * active gastroenteritis * acute kidney failure * chronic kidney failure * type-1 diabetes * inflammatory bowel disease * duodenal ulcer, * duodenal tumor * autoimmune diseases

Locations (1)

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Outcomes

Primary Outcomes

zonulin levels

Patients with scattered white spots in the duodenum had blood drawn for zonulin level immediately after the procedure.

Time frame: immediately after the procedure

Secondary Outcomes

Duodenal and gastric pathologic conditions

Biopsies from the duodenum and gastric antrum and corpus were taken during the endoscopy from patients with scattered white spots in the duodenum.

Time frame: During the endoscopy

Data from ClinicalTrials.gov

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