Calcific aortic valve disease (CAVD) is a highly prevalent, disabling and costly disorder with generally poor long-time outcomes once critical stenosis presents with symptoms. Elucidating viable therapeutic strategies for CAVD is pressing. Valvular interstitial cells (VICs) control the structure and function of aortic valve. Intra-leaflet haemorrhage (IH), commonly occurring in histologically stenotic aortic valves, while, in 2019, researchers pointed that iron deposits also presented obviously healthy valves. In line with this, later exploration from vitro showed that iron stimulation alone could not promote VICs calcification. Iron deficiency (ID) is a frequent co-morbidity in multiple chronic cardiovascular diseases such as CAVD; up to 50% of patients with severe aortic stenosis present ID. Data from a small clinical study in patients undergoing TAVI showed those in ID status appeared much higher mean transaortic gradient; whereas no studies have assessed the correlation between ID and aortic valve remodelling and dysfunction progress itself. Here, the investigators aim to investigate for a tentative correlation between ID and human aortic valve remodeling and dysfunction.
Study Type
OBSERVATIONAL
Enrollment
3,000
Serum iron
Plasma levels of serum iron will be reported in μmol/L.
Time frame: within 24 hours of admission
Total iron binding capacity
Total iron binding capacity will be reported in μmol/L.
Time frame: within 24 hours of admission
Serum transferrin receptor
Plasma levels of serum transferrin receptor will be reported in g/L.
Time frame: within 24 hours of admission
Unsaturated iron-binding capacity
Serum iron and total iron binding capacity will be combined to report unsaturated iron-binding capacity in μmol/L.
Time frame: within 24 hours of admission
Serum transferrin
Plasma levels of serum transferrin will be reported in g/L.
Time frame: within 24 hours of admission
Transferrin saturation
Serum iron and total iron binding capacity will be combined to report transferrin saturation in %.
Time frame: within 24 hours of admission
Soluble transferrin index
Serum iron and serum transferrin will be combined to report soluble transferrin index.
Time frame: within 24 hours of admission
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