Creatine and Ubiquinol for Sperm Quality

N/ACompletedNCT06202469

University of Novi Sad, Faculty of Sport and Physical Education18 enrolled

Overview

This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Oligospermia Sperm Count, Low

Interventions

Supplement 1DIETARY_SUPPLEMENT

Creatine monohydrate (5 g/day)

Supplement 2DIETARY_SUPPLEMENT

Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)

PlaceboDIETARY_SUPPLEMENT

Placebo (inulin)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 - 35 years * Sperm quality test available (at least half will have low sperm quality) * Informed consent * Healthy BMI (18.5 - 24.9 kg/m2) Exclusion Criteria: * Major chronic disease and acute injuries * History of dietary supplement use during the past 28 days * No consent to randomization * Participation in other studies

Locations (1)

FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, Serbia

Outcomes

Primary Outcomes

Sperm concentration

Number of sperm per milliliter of semen

Time frame: Change from baseline sperm concentration at 8 weeks

Secondary Outcomes

Total antioxidant capacity

Level of total antioxidant capacity in semen

Time frame: Change from baseline total antioxidant capacity at 8 weeks

Creatine kinase

Level of creatine kinase in semen

Time frame: Change from baseline creatine kinase at 8 weeks

Creatine

Level of creatine in semen

Time frame: Change from baseline creatine at 8 weeks

The World Health Organisation-Five Well-Being Index (WHO-5)

The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being.

Time frame: Change from baseline WHO-5 at 8 weeks

Data from ClinicalTrials.gov

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