This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
18
Creatine monohydrate (5 g/day)
Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)
Placebo (inulin)
FSPE Applied Bioenergetics Lab
Novi Sad, Vojvodina, Serbia
Sperm concentration
Number of sperm per milliliter of semen
Time frame: Change from baseline sperm concentration at 8 weeks
Total antioxidant capacity
Level of total antioxidant capacity in semen
Time frame: Change from baseline total antioxidant capacity at 8 weeks
Creatine kinase
Level of creatine kinase in semen
Time frame: Change from baseline creatine kinase at 8 weeks
Creatine
Level of creatine in semen
Time frame: Change from baseline creatine at 8 weeks
The World Health Organisation-Five Well-Being Index (WHO-5)
The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being.
Time frame: Change from baseline WHO-5 at 8 weeks
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