Atrophic Gastritis Predicts the Risk of Gastric Cancer

N/ARecruitingNCT06203327

Shanghai Jiao Tong University School of Medicine2,042 enrolled

Overview

Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.

Study Type

OBSERVATIONAL

Enrollment

2,042

Conditions

Atrophic Gastritis

Interventions

Esophagogastroscopy (OLGA 0-Ⅰ)OTHER

Surveillance endoscopies at years 3-5.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ability and willingness to participate in the study and to sign and give informed consent * Biopsies were collected based on the recommendation of updated Sydney system Exclusion Criteria: * under 18 or over 80 years old * history of gastrectomy * severe systemic diseases or malignancy

Outcomes

Primary Outcomes

early gastric neoplasm

histological diagnosis of high-grade dysplasia, and adenocarcinoma.

Time frame: After the baseline endoscopy, participants were scheduled for surveillance endoscopies at years 3-5 for subjects with operative link on gastritis assessment (OLGA) 0-Ⅰ, at years 2-3 for subjects with OLGA II and 1 year for subjects with OLGA III-IV.