This study will assess comparative bioavailability and effect of food on a prototype fixed-dose combination (FDC) of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in healthy subjects
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
42
A Fixed-Dose Combination of Bemnifosbuvir (BEM) and Ruzasvir (RZR)
A Fixed-Dose Combination of Bemnifosbuvir (BEM) and Ruzasvir (RZR)
Bemnifosbuvir (BEM) and Ruzasvir (RZR) as separate formulations
Atea Study Site
Cypress, California, United States
Pharmacokinetics (PK) of FDC compared to reference:(Cmax)
Maximum plasma concentration (Cmax)
Time frame: Day 1, Day 7, Day 13
Pharmacokinetics (PK) of FDC compared to reference:(AUC)
Area under the plasma concentration-time curve (AUC)
Time frame: Day 1, Day 7, Day 13
Food effect of Fixed Dose Combination of Bemnifosbuvir (BEM)/Ruzasvir (RZR):(Cmax)
Maximum plasma concentration (Cmax)
Time frame: Day 1, Day 7, Day 13
Food effect of Fixed Dose Combination of Bemnifosbuvir (BEM)/Ruzasvir (RZR):(AUC)
Area under the plasma concentration-time curve (AUC)
Time frame: Day 1, Day 7, Day 13
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