This is a prospective, randomized, placebo controlled, double-blinded study to evaluate the efficacy of a combination of nutritional ingredients on muscle health and recovery from a short bout of exhaustive exercise in healthy older adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
30
Ready to drink supplement.
Ready to drink supplement.
University of Nottingham
Derby, United Kingdom
Leg Strength
Change in Peak torque of maximum voluntary contraction (MVC)
Time frame: Pre-Exercise (Day -1) to Post Exercise Recovery (up to 7 Days)
Muscle Fatigue
Time to failure during a sub-maximal isometric contraction of the knee extensors
Time frame: Pre-Exercise (Day -1) to Post Exercise Recovery (up to 7 Days)
Muscle Soreness
100 mm visual analog scale from No Pain to Extreme Pain
Time frame: Pre-Exercise (Day -1) to Post Exercise Recovery (up to 7 Days)
Leg Strength Changes
Change in Peak torque of maximum voluntary contraction (MVC)
Time frame: Baseline to Day -1 Pre-Exercise (up to 4 Weeks)
Muscle Protein Synthesis
Change in Fractional Synthesis Rate
Time frame: Post Exercise Day 1 to Day 7
Muscle Protein Breakdown
Change in D3-3methylhistidine (D3-3MH)
Time frame: Pre-Exercise (Day -1) to Post Exercise Recovery (up to 7 Days)
Neuromuscular Function
Change in Electromyography
Time frame: Baseline up to Post Exercise Study Day 7 (up to 5 weeks)
Blood Biomarker Muscle Damage
Changes in blood biomarker of muscle damage
Time frame: Pre-Exercise (Day -1) to Post Exercise Recovery (up to 7 Days)
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Blood Biomarker Oxidative Stress
Changes in blood biomarker of oxidative stress
Time frame: Baseline up to Post Exercise Study Day 7 (up to 5 weeks)