Feasibility Trial Using an Inpatient Insulin Dosing Calculator

N/ACompletedNCT06206525

University of Washington38 enrolled

Overview

The goal of this feasibility trial is to test whether a novel insulin dosing calculator can improve blood glucose management for patients with type 2 diabetes mellitus on hospital admission. The main questions it aims to answer are: * Whether using this calculator leads to no excessive hypoglycemia? * Whether using this calculator leads to a decrease of hyperglycemia? Participants will receive initial insulin doses by the calculator on hospital admission, and the rest of care will follow standard of care. Participants will be compared with patients in the UW observational cohort who received initial insulin doses by standard of care.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Diabetes Mellitus, Type 2

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are admitted to University of Washington Medical Centers * With history of type 2 and/or steroid-induced diabetes mellitus * Receiving insulin therapy prior to admission Exclusion Criteria: * Patients who are admitted to ICU or obstetrics ward * Patients who are admitted for elective surgery or procedure * Patients who present with diabetic ketone acidosis, hyperosmolar hyperglycemic state or require intravenous insulin infusion * Patients who have no meal intake for 24 hours prior to admission, or planned nothing per oral (NPO) during the first 24 hours after admission * Patients who report low appetite (25% or less) on admission or have a significantly decreased level of consciousness that they unlikely eat right after admission * Patients who receive enteral feeding after admission * Patients who develop severe acute kidney injury needing dialysis therapy

Locations (3)

Harborview Medical Center

Seattle, Washington, United States

UW Medical Center - Northwest

Seattle, Washington, United States

UW Medical Center - Montlake

Seattle, Washington, United States

Outcomes

Primary Outcomes

Clinical significant hypoglycemia

Participates who develop blood glucose concentration lower than 54 mg/dL

Time frame: During the first 48 hours after admission

Secondary Outcomes

Mean blood glucose concentration (mg/dL)

Time frame: During the first 24 hours after admission

Clinical significant hyperglycemia

Participates who develop blood glucose concentration higher or equal to 300 mg/dL

Time frame: During the first 48 hours after admission

Hypoglycemia lower than 70 mg/dL

Participates who develop blood glucose concentration lower than 70 mg/dL

Time frame: During the first 48 hours after admission