Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery

Inclusion Criteria: * Non-pregnant, non-lactating/breastfeeding, non-incarcerated, English-speaking persons undergoing Mohs micrographic surgery (MMS) for malignant cutaneous neoplasms and receiving same-day defect repair by the MMS-performing surgeon * Able to provide written informed consent prior to initiation of any study-specific procedures * Able to swallow, retain, and absorb oral medications * All malignant cutaneous neoplasms will be included Exclusion Criteria: * On antibiotic treatment or established intolerance or contraindication to povidone-iodine * Allergy to specific oral antibiotics that are utilized as part of the Mayo Clinic Antibiotic Prophylaxis protocol (cefalexin, azithromycin, clindamycin) * Requiring oral antibiotic therapy for prophylaxis postoperative infectious endocarditis or hematogenous total joint infection * Cases where skin reconstruction is performed with non-sterile gloves * Patients with lesions on the legs, as dilute vinegar soaks are standard practice and this would be a confounder for preventing surgical site infection * Patients at increased risk for severe infections, including patients on immunosuppressive medications and biologics, patients with a history of HIV infection, chronic lymphocytic leukemia, immunodeficiency syndromes, as well as patients with insulin-dependent diabetes mellitus