The present study investigates the involvement of the gut hormone glucose-dependent insulinotropic polypeptide (GIP) in the pathophysiology of postprandial hypotension (PPH)
The study is an exploratory, randomised, placebo-controlled, double-blind crossover study comprising two experimental days with an infusion of the GIP receptor antagonist, GIP(3-30)NH2 (NH2 is the aminogroup), and placebo (saline) during a 180-minute mixed meal test (MMT). Eighteen participants, men and women, with MMT confirmed PPH will be included in the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
18
Intravenous infusion of GIP(3-30)NH2 in a concentration of 1,000 pmol/kg/min during experimental days
Intravenous infusion of isotonic saline 9 mg/ml added 0,5% human serum albumin during experimental days
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark
Nadir systolic blood pressure (SBP) (mmHg)
Baseline
Time frame: -45-0 minutes
Nadir systolic blood pressure (mmHg)
Nadir and time to nadir
Time frame: 0-180 minutes
Occurrence of PPH
(Yes/No) PPH is defined as either a drop in SBP \>20 mmHg from baseline or SBP \<90 mmHg
Time frame: 0-180 minutes
Systolic blood pressure (mmHg)
Baseline
Time frame: -45-0 minutes
Systolic blood pressure (mmHg)
Peak, nadir and iAUC (incremental area under the curve)
Time frame: 0-180 minutes
Diastolic blood pressure (mmHg)
Baseline
Time frame: -45-0 minutes
Diastolic blood pressure (mmHg)
Peak, nadir and iAUC
Time frame: 0-180 minutes
Heart rate (beats/min)
Baseline
Time frame: -45-0 minutes
Heart rate (beats/min)
Peak, nadir and iAUC
Time frame: 0-180 minutes
Stroke volumen (ml)
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Baseline
Time frame: -45-0 minutes
Stroke volumen (ml)
Peak, nadir and iAUC
Time frame: 0-180 minutes
Cardiac output (l/min)
Baseline
Time frame: -45-0 minutes
Cardiac output (l/min)
Peak, nadir and iAUC
Time frame: 0-180 minutes