The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative complications. The main questions it aims to answer are * Does the type of anesthesia have a relationship with inflammatory biomarkers? * Are inflammatory biomarkers associated with postoperative complications?
This study is planned to be a prospective observational clinical study. Patients who will undergo on-pump coronary artery bypass surgery, meet the eligibility criteria and agree to participate in the study and sign the informed patient consent form will be included in the study.Systemic immune inflammatory index, systemic inflammatory response index, neurophile lymphocyte ratio, platelet lymphocyte ratio will be calculated in the routine complete blood count of patients in the last 3 preoperative days and in the first 24 hours postoperatively.It will be evaluated whether these biomarkers are related to the anesthesia technique used, patients comorbidities and the complications that develop in the first 24 hours postoperatively. Patients will be evaluated preoperatively, intraoperatively and postoperatively; preoperative comorbidities, intraoperative anesthesia management, cross clamp, pump and surgery times, blood and blood product transfusion, inotrope use and complications that develop up to the first 24 hours postoperatively will be recorded.The anesthetic technique to be used will be determined according to the anesthesiologist's preference and will be recorded.
Study Type
OBSERVATIONAL
Enrollment
228
Ankara city hospital bilkent
Ankara, Çankaya, Turkey (Türkiye)
Preoperative systemic immune inflammatory index (SII)
It will be calculated as: platelet count x neutrophil count / lymphocyte count from routine complete blood count
Time frame: within 3 days preoperatively
Postoperative systemic immune inflammatory index (SII)
It will be calculated as: platelet count x neutrophil count / lymphocyte count from routine complete blood count
Time frame: in the first 24 hours postoperatively
Preoperative systemic inflammatory response index (SIRI)
It will be calculated as: neutrophil count x monocyte count/lymphocyte count from routine complete blood count
Time frame: within 3 days preoperatively
Postoperative systemic inflammatory response index (SIRI)
It will be calculated as: neutrophil count x monocyte count/lymphocyte count from routine complete blood count
Time frame: in the first 24 hours postoperatively
Preoperative neutrophile lymphocyte ratio (NLR)
It will be calculated as:neutrophil count/lymphocyte count from routine complete blood count
Time frame: within 3 days preoperatively
Postoperative neutrophile lymphocyte ratio (NLR)
It will be calculated as:neutrophil count/lymphocyte count from routine complete blood count
Time frame: in the first 24 hours postoperatively
Preoperative platelet lymphocyte ratio (PLR)
It will be calculated as: platelet count/lymphocyte count from routine complete blood count
Time frame: within 3 days preoperatively
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Postoperative platelet lymphocyte ratio (PLR)
It will be calculated as: platelet count/lymphocyte count from routine complete blood count
Time frame: in the first 24 hours postoperatively
Preoperative c-reactive protein
from routine preoperative blood sample ( milligram/decilitre)
Time frame: within 3 days preoperatively
Preoperative procalcitonin
from routine preoperative blood sample ( microgram/litre)
Time frame: within 3 days preoperatively
Postoperative c-reactive protein
from routine postoperative blood sample ( milligram/decilitre)
Time frame: in the first 24 hours postoperatively
Postoperative procalcitonin
from routine postoperative blood sample ( microgram/litre)
Time frame: in the first 24 hours postoperatively
Postoperative complications
Postoperative complications consisting of: * newly developed atrial fibrillation * need for cardiac pacing * need for ECMO (Extracorporeal membrane oxygenation) * need for IABP (Intra-Aortic Balloon Pump) * prolonged mechanical ventilation * pericardial effusion * cardiac arrest * cerebrovascular event * delirium * exitus * other complications.
Time frame: within the first 24 hours after surgery
Patient comorbidities
Patient comorbidities will be assessed
Time frame: preoperative within 48 hours
Transfusion requirement
Incidence of transfusion of blood and blood products to the patient
Time frame: during the operation
Inotrope requirement
Incidence of inotrope usage, inotropes consisting of: * noradrenaline * dopamine * dobutamine
Time frame: during the operation